mankhwala
Ubwino Wapamwamba wa L-Glutathione Wochepetsedwa CAS 70-18-8 wa Glutathione Wosamalira Khungu
Zambiri zamalonda
Chithunzi cha C10H17N3O6S
MW: 307.32
CAS: 70-18-8
1.Glutathione ndi gulu la tripeptide lopangidwa ndi glutamic acid, cysteine ndi glycine kupyolera mumagulu a peptide.Ndiwofunikira kwambiri otsika mamolekyu mercaptan m'maselo a mammalian pansi pa kupsinjika kwa antioxidant.
2.Glutathione (GSH) ndi gulu la tripeptide lomwe limapangidwa ndi condensation ya glutamic acid, cysteine ndi glycine kupyolera mumagulu a peptide.Dzina lake lamankhwala ndi γ- Mapangidwe a l-glutamyl-l-cysteyl-glycine akuwonetsedwa mu chithunzi 1chemicalbook.Malinga ndi kapangidwe kachiwerengero, GSH ndi yosiyana ndi ma peptides ndi mapuloteni ena.Pali chomangira chapadera cha peptide mu molekyulu yake, yomwe imapangidwa ndi glutamic acid γ- Carboxyl (- COOH) ndi cysteine α- Peptide chomangira chopangidwa ndi condensation ya amino - (- NH2).
3.Kulemera kwa molekyulu ya glutathione ndi 307.33, malo osungunuka ndi 189 ~ 193 ℃ (kuwonongeka), kristalo ndi yopanda mtundu, yowonekera, yowonda, ndipo isoelectric point ndi 5.93.Imasungunuka m'madzi, imasungunuka mowa, ammonia yamadzimadzi ndi methyl formamide, koma osasungunuka mu mowa, ether ndi acetone.GSH yokha ndiyo yomwe imakhala ndi zochitika zathupi m'thupi, ndipo GSSG imatha kuchita ntchito yofunika kwambiri ya thupi pambuyo pochepetsa.GSH sikophweka kusunga pansi pa ntchito yamadzi apamwamba, ndipo ikhoza kusungidwa mokhazikika kwa nthawi yaitali pokhapokha ngati ntchito yamadzi ikuyendetsedwa pansi pa 0.3.Kafukufuku wasonyeza kuti mu vitamini ccchemicalbook amadzimadzi njira munali GSH (ph3.3), chifukwa cha kuchepetsa amphamvu vitamini C, GSH mu njira si oxidized kwa GSSG, koma kuwonongeka kwake liwiro imathandizira;GSSG mu vitamini C yankho lamadzimadzi silidzasinthidwa kukhala GSH, ndipo kukhazikika kwake kosungirako kuli bwino kwambiri.Komanso, GSSG kulowetsedwa m'kamwa kumatha kuchepetsedwa kukhala GSH kumtunda kwa matumbo aang'ono, komanso pamwamba pa maselo ang'onoang'ono a m'matumbo a epithelial γ- GTP (omwe amawola GSH kukhala glutamic acid ndi Cys Gly) ndi dipeptidase amathanso kuchita zofunikira za thupi. ntchito.
4.Glutathione imapezeka kwambiri mu zinyama ndi zomera, ndipo zomwe zili mu yisiti ya wophika mkate, nyongolosi ya tirigu ndi chiwindi cha nyama ndizokwera kwambiri, mpaka 100 ~ 1000mg/100g;Lilinso ndi magazi a anthu ndi nyama, monga 26chemicalbook ~ 34mg/100g m'mwazi wa anthu, 58 ~ 73mg/100g mu magazi a nkhuku, 10 ~ 15mg/100g mu magazi a nkhumba ndi 14 ~ 22mg/100g mu magazi agalu.GSH imapezekanso m'masamba ambiri, mbatata ndi mbewu.
Kugwiritsa ntchito
1.Kuchepetsa glutathione ndi peptide yaing'ono ya molekyulu, yomwe imakhala yochuluka kwambiri mu zamoyo, makamaka m'maselo a chiwindi.Itha kuteteza nembanemba yama cell a chiwindi, kulimbikitsa ntchito ya enzyme ya chiwindi, ndikuphatikiza ndi mankhwala ambiri oopsa mu chemicalbook kuti achotse poizoni.Zimakhudza kwambiri kuwonongeka kwa chiwindi, matenda a chiwindi ndi matenda ena omwe amayamba chifukwa cha mankhwala osokoneza bongo, uchidakwa ndi zifukwa zina.
2.Ili ndi ntchito za antioxidation, scavenging free radicals, detoxification, kulimbikitsa chitetezo chokwanira, kuchedwa kukalamba, anti-cancer, anti radiation kuwonongeka ndi zina zotero.
3.Biochemical reagents ndi antidotes makamaka ntchito poyizoni wa heavy metals, acrylonitrile, fluoride, carbon monoxide ndi organic solvents.
4.Endogenous antioxidants yomwe imagwira ntchito yofunika kwambiri pakuchepetsa mitundu ya okosijeni yokhazikika yomwe imapangidwa panthawi yama cell metabolism komanso kupuma kwadzidzidzi.Glutathione-S-transferase imathandizira kupanga glutathione sulfide ndi xenobiotics, leukotrienes ndi mamolekyu ena okhala ndi electrophilic centers.Glutathione imapanganso zomangira za disulfide ndi zotsalira za cysteine m'mapuloteni.Kupyolera mu njirazi, zingakhale ndi zotsatira zachilendo zochepetsera mphamvu za anticancer agents.
