mankhwala
Tetracaine hydrochloride
Zambiri zamalonda
Mtengo wa C15H25ClN2O2
MW: 300.82
CAS: 136-47-0
1.Tetracaine hydrochloride ndi mankhwala othandiza kwambiri am'deralo omwe amatha kulepheretsa kugwira ntchito kwa mitsempha mosinthika.Amagwiritsidwa ntchito polowetsa anesthesia, mitsempha ya mitsempha, anesthesia ya epidural, etc. poyerekeza ndi procaine, zotsatira zake za anesthesia ndizofunika kwambiri, ndipo zakhala zikugwiritsidwa ntchito kwambiri kuchipatala.Kupyolera mu kuphunzira njira zomwe zilipo kaphatikizidwe, zimapezeka kuti kaphatikizidwe ka p-butylamino benzoic acid ndi sitepe yofunika kwambiri mu kaphatikizidwe ka tetracaine hydrochloride, yomwe ili ndi zofooka za zipangizo zosakhazikika kapena zokolola zochepa.Asayansi asintha izi.Mu 1981, adaganiza zopanga p-butylamino benzoic acid ndi alkylating p-aminobenzoic acid ndi 1-Bromobutane.Komabe, chifukwa cha kupangika kosalephereka kwa zinthu zopangidwa ndi dibutylation komanso kusakhazikika kwazinthu zopangira, njira iyi siyoyenera kupanga mafakitale.
2.Tetracaine hydrochloride imagwiritsidwa ntchito mucosal surface anesthesia, conduction anesthesia, epidural anesthesia ndi subbarachnoid anesthesia;Ntchito ophthalmic pamwamba opaleshoni, si constrict mitsempha, si kuwononga corneal epithelium, ndipo si kuonjezera intraocular kuthamanga.
3. Mankhwalawa amatha kupititsa patsogolo mphamvu ya mitsempha ya cisatracurium, ndipo mlingo wake uyenera kuchepetsedwa ukaphatikizidwa.Ikaphatikizidwa ndi adrenaline, imatha kusokoneza mitsempha yamagazi, kuchepetsa kutuluka kwa magazi, kuyamwa kwamankhwala pang'onopang'ono, ndikutalikitsa nthawi yochitapo kanthu.Koma kuphatikiza ziwirizi si koyenera kwa odwala matenda a mtima, matenda oopsa, hyperthyroidism, zotumphukira mtima matenda ndi zina zotero.Hyaluronidase amatha kuonjezera kufalikira kwa mankhwalawa, kufulumizitsa kuyambika kwa opaleshoni, kuchepetsa kutupa kwa m'deralo, ndikuletsa mapangidwe a hematoma.Komabe, hyaluronidase imathanso kufulumizitsa kuyamwa kwa mankhwalawa, zomwe zimapangitsa kuwonjezeka kwa anti chemical Book kawopsedwe ka mankhwalawa.Mankhwalawa amachokera ku p-aminobenzoic acid (PABA).Sulfonamides imakhala ndi antibacterial effect poletsa PABA ya mabakiteriya.Mankhwalawa akaphatikizidwa ndi sulfonamides, mphamvu ya antibacterial yotsirizirayi idzalephereka, kotero awiriwo sayenera kuphatikizidwa.Mankhwalawa ndi acidic ndipo sayenera kusakanikirana ndi mankhwala amadzimadzi amchere;Ngakhale mankhwala a acidic amatha kusokoneza kufunika kwa mankhwalawa chifukwa cha pH yosiyana, zomwe zimapangitsa kuchepa kapena kuchedwa nthawi yoyambira.Kukonzekera kwa ayodini kungayambitse mvula ya mankhwalawa, kotero malo ojambulira mankhwalawa sangathe kugwiritsidwa ntchito.
Kugwiritsa ntchito
Mankhwalawa ndi oletsa kwanthawi yayitali ester.Makhalidwe ake ndi awa: kulowa mwamphamvu kwa mucosa, koyenera kwa anesthesia padziko, ndipo palibe zotsatirapo monga vasoconstriction, mydriasis, kuvulala kwa cornea pambuyo pa madontho a maso.Amagwiritsidwa ntchito kwambiri mu ophthalmology.Mphamvu yamankhwala am'deralo ndi kawopsedwe ndi pafupifupi nthawi 10 kuposa procaine.Pambuyo jekeseni, mphamvu ya mankhwala ochititsa dzanzi imawonekera pang'onopang'ono (pafupifupi mphindi 10), ndipo kagayidwe kake kamachedwanso pambuyo poyamwa.Nthawi ya anesthesia yapafupi ndi 3ij, h, -j.za.Izo makamaka ntchito padziko opaleshoni ya diso, mphuno ndi mmero mucosa, ndipo kawirikawiri ntchito conduction opaleshoni ndi epidural opaleshoni.Nthawi zambiri, sichimagwiritsidwa ntchito polowetsa anesthesia chifukwa cha poizoni wake wambiri.
